Sperm DNA Fragmentation Test (SDF / DFI)
An advanced semen test that measures sperm DNA damage and helps guide fertility treatment decisions.
Purpose
A semen analysis may look normal even when sperm DNA quality is affected. The SDF/DFI test checks the level of DNA damage in sperm and is often recommended when there is unexplained infertility, repeated IVF failure, or recurrent pregnancy loss.
Measures DNA damage in sperm.
Procedure
A semen sample is tested in the lab to measure sperm DNA fragmentation and guide the next fertility step.
Sample Collection
A semen sample is collected as per clinic instructions (similar to standard semen testing).
Laboratory Testing
Procedure: Lab test using semen sample; results guide fertility treatment planning. The lab measures the percentage/level of DNA fragmentation.
Report Interpretation
Your specialist reviews the result in the context of semen analysis, age, and fertility history.
Treatment Planning
Next steps are decided—lifestyle changes, supplements, repeat testing, or ART planning depending on the case.
Clinical Relevance
High DNA fragmentation is linked to lower fertilization, implantation failure, miscarriage, and poor IVF outcomes. It helps explain failures even when count/motility appear acceptable.
Clinical Evidence
Interventions include antioxidants, lifestyle modification, and advanced sperm selection techniques (ICSI, PICSI).
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